9(S)-benzoylamino-octahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepine-1(S)-carboxylic acid → HCID 18465736, compound

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Reaction Steps

was prepared from the acid (212e) and (3S,4RS) t-butyl N-(allyloxycarbonyl)-3-amino-4-hydroxy-4-(5,7-dichlorobenzoxazol-2-yl)butanoate (204) by an analogous method as that used for compound 215e to afford a mixture of diastereomers (613 mg, 87%) as a glass: IR film) 3328, 1229, 1660, 1534, 1454, 1422, 1399, 1276, 1254, 1155; 1H NMR (CDCl3) δ7.80 (2H, d), 7.60-7.35 (5H, m), 1155; 1H NMR (CDCl3) δ7.80 (2H, d), 7.60-7.35 (5H, m), 7.05 (2H, m), 5.13 (3H, m), 4.74 (1H, m), 4.51 (1H, m), 3.25 (1H, m), 3.1-2.6 (5H, m), 2.33 (1H, m), 2.1-1.5 (5H, m), 1.43 and 1.41 (9H combined, 2×s). MS ES+ Da/e 688 (M+1)+ Cl35 55%, 690 (M+1)+ Cl37 35%, 328 100%.

Provenance & Evidence