HCID 15490830, compound → 2-tert-Butoxycarbonylamino-3-(3-aminopyridin-2-ylamino)-propionic acid

HRID 2230472Notes

Reaction equation

HRID 2230472 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][NH:14][C:15]1C=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-])=O)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].COC(=O)C[N:28]1C2C=CC=CC=2NC[C@H](NC(OC(C)(C)C)=O)C1=O>>[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][NH:14][C:15]1[C:16]([NH2:21])=[CH:17][CH:18]=[CH:19][N:28]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 15490830HCID 15490830, compoundHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

Product 1

HCID 184658332-tert-Butoxycarbonylamino-3-(3-aminopyridin-2-ylamino)-propionic acid

Procedure

was prepared by a similar method to (2S) 2-tert-Butoxycarbonylamino-3-(2-aminophenylamino)-propionic acid in Step B of the synthesis of 600a/103 to give 3.68 g (quant.) as a dark solid.

Workup

  1. customto give 3.68 g (quant.) as a dark solid

Sources & evidence

ORD record
ord-13cc3fe9b5e142d39d36830cdfd209d6
Source dataset
uspto-grants-2002_07
Patent number
US06423840B1

Reaction notes

Loading…