HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzyl alcohol → (3S,2RS) 3-Allyloxycarbonylamino-2-(4-chlorobenzyl)oxy-5-oxotetrahydrofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzyl alcohol | HCID 13397 | — |
| Reactant | (3S,2RS)3-allyloxycarbonylamino-2-benzyloxy-5-oxotetrahydrofuran | HCID 10989944 | — |
| Product | (3S,2RS) 3-Allyloxycarbonylamino-2-(4-chlorobenzyl)oxy-5-oxotetrahydrofuran | HCID 59947520 | — |
Reaction Steps
was synthesized from allyloxycarbonylamino-β-tert-butyl aspartate by the methods employed by Chapman (Bioorg. & Med. Chem. Lett., 2, pp.6.15-6.18 (1992)) to prepare (3S,2RS)3-allyloxycarbonylamino-2-benzyloxy-5-oxotetrahydrofuran using 4-chlorobenzyl alcohol instead of benzyl alcohol to afford 1.84 g of 2101a as a crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423840B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-ae03ebf46e824b15941dba057077b0f1 |
| Source note | uspto-grants-2002_07 |