Potassium Bromide → 9-Benzamido-N-(2-cyclopentyloxy-5-oxo-tetrahydrofuran-3-yl)-6,10-dioxo-1,2,3,4,7,8,9,10-octahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Bromide	HCID 253877	—
Reactant	9-Benzoylamino-6,10-dioxo-1,2,3,4,7,8,9,10-octahydro-N-(2-benzyloxy-5-oxotetrahydrofuran-3-yl)-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxamide	HCID 18465729	—
Solvent	Dichloromethane	HCID 6344	—
Product	9-Benzamido-N-(2-cyclopentyloxy-5-oxo-tetrahydrofuran-3-yl)-6,10-dioxo-1,2,3,4,7,8,9,10-octahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxamide	HCID 18465851	—

Reaction Steps

was prepared by a similar method as 213e, (74%) as a colourless solid: mp. 172-80° C.; [α]D23 −91.5° (c 0.1, CH2Cl2); IR (KBr) 3290, 1792, 1677, 1657, 1642, 1544, 1429, 1280, 1259, 1124, 977; 1H NMR (CDCl3) δ7.80 (2H, m), 7.46 (3.5H, m), 7.00 (1H, d, J=6.7), 6.48 (0.5H, d, J=7.9), 5.55 (0.5H, d, J=5.3), 5.19 (2H, s+m), 4.93 (0.5H, m), 4.62 (1.5H, m), 4.34 (1H, m), 4.18 (0.5H, m), 3.28-2.70 (4H, m), 2.49-2.29 (2H, m), 205-1.48 (15H, m).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06423840B1
Source dataset	uspto-grants-2002_07
ORD ID	ord-190d000bfd9040edaa6c10fc9dd25406
Source note	uspto-grants-2002_07