(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-methoxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide → (3S)-2-Oxo-3-benzoylamino-5-acetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide

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Reaction Steps

was synthesized from 600b via methods used to prepare 688a from 600b afford 30 mg of 693, 1H NMR (CD3OD) δ1.7(s, 3H), 1.8(s, 3H), 2.51(d, 1H, 2.6(m, 1H), 2.8(m, 1H), 3.0(m, 1H), 3.75(br. d, 2H), 4.0-4.1(dd, 2H), 4.5-5.0(m, 6H), 5.45(s, 1H), 5.55(s, 1H), 7.15-7.85(m, 14H).

Provenance & Evidence