Emedastine EP Impurity E → 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethyoxyethyl)-1H-benzimidazol-2-yl) 1,4 diazepan-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine

Participants

Role	Name	HCID	Charge
Reactant	Emedastine EP Impurity E	HCID 9984168	—
Reactant	3-(3,4-Dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)-3-pyrrolidineethanol methansulfonate	HCID 15840899	—
Product	1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethyoxyethyl)-1H-benzimidazol-2-yl) 1,4 diazepan-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine	HCID 18464603	—

Reaction Steps

Prepare by the method of Example 1.6 using 1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-methanesulfonyloxyethyl)pyrrolidine and 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06423704B1
Source dataset	uspto-grants-2002_07
ORD ID	ord-d38ebec93c9340ff91803e74f905e692
Source note	uspto-grants-2002_07