Methanol → Methyl 2-methoxy-5-methylthiobenzoate

HRID 2230596노트

반응식

HRID 2230596 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:4]=1[C:5]([OH:7])=[S:6].[CH3:13]O.S(Cl)(Cl)=O>CCCCCC.ClCCl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:4]=1[C:5]([O:7][CH3:13])=[S:6]

참가 물질

5

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178489964HCID 178489964, 화합물

생성물 1

HCID 53727199Methyl 2-methoxy-5-methylthiobenzoate

시약·촉매·용매 1

HCID 21226440Methylenechloride Hexane용매

실험 절차

Combine 2-methoxy-5-methylthiobenzoic acid (6.82 g, 34.4 mmol) and methanol (65 mL). Cool in an ice bath. Add slowly dropwise thionyl chloride (2.8 mL, 38 mmol). Warm to ambient temperature. After 18 hours, evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 25% hexane/dichloromethane to give methyl 2-methoxy-5-methylthiobenzoate: Rf=0.06 (silica gel, 65% hexane/dichloromethane).

후처리

  1. temperatureCool in an ice bath
  2. customevaporate in vacuo
  3. customto give a residue

출처 및 근거

ORD 기록
ord-566263aae48040759814fbabe3ba8798
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06423704B1

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