反应详情

Combine methyl 2-methoxy-5-methylsulfonylbenzoate (2.24 g, 9.2 mmol) and a 1 M aqueous potassium hydroxide solution (10 mL, 10 mmol). Heat to reflux. After 2 hours, filter while still hot, cool in an ice bath, and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL) to give a solid. Collect the solid by filtration, rinse with water, and dry to give the title compound: mp; 189-191° C. Elemental Analysis Calculated for C9H10SO5: C, 46.95; H, 4.38. Found: C, 46.76; H, 4.40.

1. temperatureHeat to reflux
2. filtrationfilter while still hot,
3. temperaturecool in an ice bath
4. additionacidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL)
5. customto give a solid
6. customCollect the solid
7. filtrationby filtration
8. washrinse with water
9. customdry