2-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid → 1-(2-Methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine

HRID 2230632Notes

Reaction equation

HRID 2230632 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([S:17]([CH3:20])(=[O:19])=[O:18])=[N:15][N:14]=[N:13]2)=[CH:8][C:4]=1[C:5]([OH:7])=O.Cl.[CH2:22]([O:24][CH2:25][CH2:26][N:27]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[N:29]=[C:28]1[N:36]1[CH2:42][CH2:41][CH2:40][N:39]([CH2:43][CH2:44][C:45]2([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[CH2:49][CH2:48][NH:47][CH2:46]2)[CH2:38][CH2:37]1)[CH3:23]>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([S:17]([CH3:20])(=[O:19])=[O:18])=[N:15][N:14]=[N:13]2)=[CH:8][C:4]=1[C:5]([N:47]1[CH2:48][CH2:49][C:45]([CH2:44][CH2:43][N:39]2[CH2:40][CH2:41][CH2:42][N:36]([C:28]3[N:27]([CH2:26][CH2:25][O:24][CH2:22][CH3:23])[C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[N:29]=3)[CH2:37][CH2:38]2)([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[CH2:46]1)=[O:7]

Participants

3

Reactant 2

HCID 184644382-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acidHCID 184649573-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid

Product 1

HCID 184645741-(2-Methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine

Procedure

Prepare by the method of Example 56.1 using 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoic acid and 3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt (prepared from (−)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine (R,R)-di-p-anisoyltartaric acid salt) to give the title compound.

Sources & evidence

ORD record
ord-ebeff21ffe1d4f8681cfbd51426a1403
Source dataset
uspto-grants-2002_07
Patent number
US06423704B1

Reaction notes

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