HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2230644Generated: October 30, 2026
Methyl 5-(chloromethyl)-2-methoxybenzoate → Methyl 2-methoxy-5-(methylthiomethyl)benzoate
https://huagongshe.com/reaction/2230644
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 5-(chloromethyl)-2-methoxybenzoate | HCID 240622 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-methoxy-5-(methylthiomethyl)benzoate | HCID 18464711 | — |
Reaction Steps
Combine methyl 2-methoxy-5-chloromethylbenzoate (5 mmol) and dimethylformamide (10 mL). Cool in an ice bath and add sodium thiomethoxide (15 mmol). Heat to 75° C. After 5.5 hours, partition the reaction mixture between water and ethyl acetate. Extract the organic layer with water, dry over Na2SO4, filter, and concentrate in vacuo to give methyl 2-methoxy-5-(methylthiomethyl)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06423704B1 |
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| Source dataset | uspto-grants-2002_07 |
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| ORD ID | ord-51401978f16240a5bd2ed0ddaa5c29cb |
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| Source note | uspto-grants-2002_07 |
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