HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → 2-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 2-(Oxan-2-yloxy)ethan-1-ol | HCID 4166833 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether | HCID 18464684 | — |
Reaction Steps
According to the procedure of Tet. Let., 35, 5997-6000 (1994), combine 1-hydroxy-2-tetrahydropyran-2-yloxyethane (J. Chem. Soc. Chem. Commun., 1766 (1990)) (5.0 mmol), 1,1-diethylazodicarboxylate (10 mmol), 2,2,2-trifluoroethanol (100 mmol), and tributylphosphine (10 mmol) in benzene (100 mL). After 6 hours, concentrate in vacuo to give a residue. Chromatograph on silica gel to give 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluorethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423704B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-9446a34bee92493cba45ec7bd8db8405 |
| Source note | uspto-grants-2002_07 |