Hydroxyamine hydrochloride → Methyl 2-methoxy-5-formylbenzoate oxime

Participants

Reaction Steps

Combine methyl 2-methoxy-5-formylbenzoate (5.0 g, 25.9 mmol), hydroxylamine hydrochloride (8.55 g, 133 mmol), and sodium acetate (10.25 g, 125 mmol) in ethanol/water (200 mL, 1/1). Heat: to 50° C. After 1 hour, pour the reaction mixture onto ice to give a solid. Collect the solid byfiltration to give methyl 2-methoxy-5-formylbenzoate oxime: Rf=0.76 (silica gel, 9/1 dichloromethane/methanol).

Provenance & Evidence