HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Hydroxy-2-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-hydroxy-2-methoxybenzoate | HCID 592162 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Hydroxy-2-methoxybenzoic acid | HCID 18464607 | — |
Reaction Steps
Combine methyl 2-methoxy-5-hydroxybenzoate (0.37 g, 2.0 mmol) and a 1 M aqueous sodium hydroxide solution (20 mL, 20 mmol) in methanol (20 mL). After 2 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423704B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-de60877105fa4ec6a2b924425153b0d7 |
| Source note | uspto-grants-2002_07 |