HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 6-methoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 3-(chloropropoxy)-6-methoxy-2H-1-benzopyran-2-one | HCID 86748753 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 6-methoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927674 | 94% |
Reaction Steps
Method B (9 h at 70° C.); starting materials: 7-[3-(chloropropoxy)-6-methoxy-2H-1-benzopyran-2-one (see example 69) and 1-phenylpiperazine; yield 94%; fusion point 82° to 83° (from isopropanol and TBME). Fumarate: method E; yield 94%; fusion point 168° to 170° C. (from isopropanol and TBME).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-6847489470b44f3c997251298a9f7a2a |
| Source note | uspto-grants-1995_06 |