HCID 20522469, compound → HCID 14158468, compound

Participants

Reaction Steps

According to the same procedure as in Example 1, 1-(1-methoxycarbonyl-2-methylpropyl)-3-acetylamino-4-phenylazetidin-2-one (230 mg.) was subjected to hydrogenolysis at 50° C. in methanol (20 ml.) in the presence of a 10% Pd-C (310 mg.) under a hydrogen pressure of one atmosphere. The reaction was completed in 18 hours. The same after-treatment as in Example 1 was followed to give methyl ester of N-acetylphenylalanylvaline (220 mg., yield: 95.5%).

Provenance & Evidence