HCID 20522467, compound → L-Alanine, N-acetyl-L-phenylalanyl-

Participants

Reaction Steps

According to the same procedure as in Example 1, 1-(1-methoxycarbonyl-2-phenylethyl)-3-acetylamino-4-phenylazetidin-2-one (300 mg.) was subjected to hydrogenolysis at 50° C. in methanol (30 ml.) under a hydrogen pressure of one atmosphere in the presence of a 10% Pd-C (350 mg.). The reaction completed in 18 hours. The same after-treatment as in Example 1 was followed to give methyl ester of N-acetylphenylalanylalanine (280 mg., yield: 92.8%) melting at 128.0°-132.0° C.

Provenance & Evidence