Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Nitroaniline | HCID 7423 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 22724130 | HCID 22724130 | 21% |
Reaction Steps
A mixture of 3-nitroaniline (6.14 g), 2-chloropyrimidine (4.85 g) and potassium carbonate (6.15 g) in dimethylsulfoxide (50 ml) was heated at 170° C. for 5 hours. The mixture was cooled and poured into a mixture of ethyl acetate and water. The organic phase was washed with brine, dried over magnesium sulfate and concentrated. The resulting solid was collected and washed with isopropyl ether to give 2-(3-nitrophenylamino)pyrimidine (1.92 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06426345B1 |
|---|
| Source dataset | uspto-grants-2002_07 |
|---|
| ORD ID | ord-d81cbeb0a69d4ce5a4169da99356e376 |
|---|
| Source note | uspto-grants-2002_07 |
|---|
