HCID 20522463, compound → L-Phenylalanyl-L-valine

Participants

Reaction Steps

According to the same procedure as in Example 1, 1-(1-methoxycarbonyl-2-methylpropyl)-3-azido-4-phenylazetidin-2-one (500 mg.) was subjected to hydrogenolysis at 50° C. in ethanol (30 ml.) under a hydrogen pressure of one atmosphere in the presence of a 10% Pd-C (175 mg.). The reaction was completed in 19 hours. The same after-treatment as in Example 1 was followed to give methyl ester of phenylalanylvaline (378 mg., yield: 81.9%), which was an oil.

Provenance & Evidence