Ethanol → HCID 131712850, compound

Participants

Reaction Steps

According to the same procedure as in Example 1, 1-(1-methoxycarbonyl-2-methylpropyl)-3-benzyloxy-4-phenylazetidin-2-one (560 mg.) was subjected to hydrogenolysis at room temperature in ethanol (30 ml.) under a hydrogen pressure of one atmosphere in the presence of a 10% Pd-C (170 mg.). The reaction was completed in 38 hours. The same after-treatment as in Example 1 was followed to give methyl ester of α-hydroxy-β-phenylpropionylvaline (400 mg., yield: 93.7%), which was an oil.

Provenance & Evidence