Ethanol → HCID 131712851, compound

Participants

Reaction Steps

According to the same procedure as in Example 1, Diastereomer A (700 mg.) of 1-(1-methoxycarbonylethyl)-3-benzyloxy-4-phenylazetidin-2-one, which had been obtained in Example 5, was subjected to hydrogenolysis at room temperature in ethanol (40 ml.) under a hydrogen pressure of one atmosphere in the presence of a 10% Pd-C (220 mg.). The reaction was completed in 12 hours. The same after-treatment as in Example 1 was followed to give methyl ester of α-hydroxy-β-phenylpropionylalanine (468 mg., yield: 90.5%), which was an oil.

Provenance & Evidence