Methanol → HCID 131712852, compound

HRID 223100Notes

Reaction equation

HRID 223100 reaction equation
C[O:2][C:3]([CH:5]([N:13]1[CH:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:15](OCC2C=CC=CC=2)[C:14]1=[O:31])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].C[OH:33]>[Pd]>[OH:33][C@@:5]([C:3]([OH:2])=[O:4])([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[NH:13][C:14](=[O:31])[CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 13043937HCID 13043937, compound

Product 1

HCID 131712852HCID 131712852, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

According to the same procedure as in Example 1, 1-(1-methoxycarbonyl-2-phenylethyl)-3-benzyloxy-4-phenylazetidin-2-one (1.0 g.) was subjected to hydrogenolysis at 50° C. in methanol (50 ml.) under a hydrogen pressure of one atmosphere in the presence of a 10% Pd-C (255 mg.). The reaction was completed in 48 hours. The same after-treatment as in Example 1 was followed to give methyl ester of α-hydroxy-β-phenylpropionylphenylalanine (784 mg., yield: 100%), which was an oil.

Sources & evidence

ORD record
ord-2f8b4e10c4a54e87bfcc00d9315494c1
Source dataset
uspto-grants-1982_10
Patent number
US04352752

Reaction notes

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