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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2231016Generated: October 31, 2026

Phenyl Isothiocyanate → HCID 22723988, compound

https://huagongshe.com/reaction/2231016

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenyl IsothiocyanateHCID 7673—
ReactantHCID 22724309HCID 22724309—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 22723988HCID 2272398853.4%

Reaction Conditions

Temperature80 °C

Reaction Steps

A mixture of 4-(3-aminophenyl)-2-benzyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (150 mg), phenylisothiocyanate (79 mg) in 1,4-dioxane (2 ml) was stirred at 80° C. for 4 hours. The precipitates were collected and washed with isopropyl ether to give 2-benzyl-3-oxo-4-[3-(3-(phenyl)thioureido)phenyl]-3,4-dihydropyrido[2,3-b]pyrazine (113 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06426345B1
Source datasetuspto-grants-2002_07
ORD IDord-0e42b4c657e0472ab241a3388ecf7f46
Source noteuspto-grants-2002_07