Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

After 1-(1(S)-t-butoxycarbonylethyl)-3(S)-azido-4(R)-phenylazetidin-2-one (200 mg., 0.63 mmol) was hydrogenated in 50 ml. of ethanol under ambient pressure at room temperature for 4 hours, using a 10% Pd-C (200 mg.) as a catalyst, 1 normal (1 N) hydrochloric acid (0.76 ml.) was added thereto. Then, the hydrogenation under ambient pressure was continued further for 15 hours at 50° C. to give quantitatively hydrochloride of t-butyl ester of L-phenylalanyl-L-alanine.

Provenance & Evidence