Ethanol → HCID 22724364, compound

HRID 2231026Notes

Reaction equation

HRID 2231026 reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[C:11](=[O:12])[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])=[O:21])[CH:14]=2)[C:9]2[N:31]=[CH:32][CH:33]=[CH:34][C:8]=2[N:7]=1)([OH:3])=[O:2].[CH2:35](O)[CH3:36]>>[CH2:35]([O:2][C:1]([CH2:4][CH2:5][C:6]1[C:11](=[O:12])[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])=[O:21])[CH:14]=2)[C:9]2[N:31]=[CH:32][CH:33]=[CH:34][C:8]=2[N:7]=1)=[O:3])[CH3:36]

Participants

3

Reactant 2

HCID 702EthanolHCID 22724153HCID 22724153, compound

Product 1

HCID 22724364HCID 22724364, compound

Procedure

To a suspension of 2-(2-carboxyethyl)-3-oxo-4-[3-[3-(2-methoxyphenyl)ureido]phenyl]-3,4-dihydropyrido[2,3-b]pyrazine (0.15 g) in ethanol (9 ml) was added conc. sulfonic acid (0.9 ml) and the mixture was refluxed for 30 minutes. After cooling, the reaction mixture was neutralized and ethanol was evaporated. Crystalline materials formed were collected, washed with water and dried to give 2-(2-ethoxycarbonylethyl)-3-oxo-4-[3-[3-(2-methoxyphenyl)ureido]phenyl]-3,4-dihydropyrido[2,3-b]pyrazine (0.12 g).

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureAfter cooling
  3. customethanol was evaporated
  4. customCrystalline materials formed
  5. customwere collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-e9417649e0504c7eaf9964708473f4c8
Source dataset
uspto-grants-2002_07
Patent number
US06426345B1

Reaction notes

Loading…