HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1(S)-Benzyloxycarbonyl-3-methylbutyl)-3-azido-4-phenylazetidin-2-one → L-Phenylalanyl-L-leucine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1(S)-Benzyloxycarbonyl-3-methylbutyl)-3-azido-4-phenylazetidin-2-one | HCID 22821671 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | L-Phenylalanyl-L-leucine | HCID 76808 | — |
Reaction Steps
1-(1(S)-Benzyloxycarbonyl-3-methylbutyl)-3-azido-4-phenylazetidin-2-one (200 mg., 0.51 mmol) was hydrogenated in 10 ml. of ethanol at 50° C. for 19 hours under ambient pressure using a 10% Pd-C (270 mg.) as a catalyst to give D/L-phenylalanyl-L-leucine quantitatively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04352752 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-420b9636b1154624a8cf612f4ce600e2 |
| Source note | uspto-grants-1982_10 |