Water → HCID 22724239, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-bromomethyl-4-(3-biphenylyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (200 mg) in acetonitrile was added triethylamine (0.14 ml) and morphorine (0.089 ml). The reaction mixture was stirred for 5 hours at 60° C. The mixture was poured into water and extracted by ethyl acetate. The organic layer was evaporated. The crude product was purified by chromatography (SiO2) to obtain 2-(1-morpholinomethyl)-4-(3-biphenylyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (110 mg) as yellow powder.

Provenance & Evidence