HCID 18463943, compound → HCID 18463943, compound

Participants

Reaction Steps

3-(2-(6-[(Isoquinoline-1-carbonyl)-amino]-3,7-dioxo-2-propyl-[1,2]diazepan-1-yl)-acetylamino)-4-oxo-butyric acid (11b) was prepared from isoquinoline-1-carboxylic acid {2-[(2-benzyloxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-3,7-dioxo-1-propyl-[1,2]diazepan-4-yl}-amide (10b, diastereomers) (95 mg, 0.16 mmol) by the method used to prepare 11a to afford 28 mg (35% yield) of the title compound. 1H-NMR (500 MHz, CDCl3/CD3OD=0.5 mL/3 drops) δ 0.90-1.00 (t, 3H), 1.65-1.80 (m, 2H), 2.10-2.28 (m, 1H), 2.32-2.40 (m, 1H), 2.47-2.80 (m, 3H), 3.05-3.18 (m, 1H), 3.30-3.51 (m, 2H), 4.00-4.55 (m, 3H), 5.10-5.20 (m, 1H), 7.75-8.05 (m, 4H), 8.49 (s, 1H), 8.90-9.00 (m, 1H). Analytical HPLC: 6.26 min. LC-MS (ES+): m/e=498 (M+H+).

Provenance & Evidence