HCID 18463921, compound → HCID 18463943, compound

Participants

Reaction Steps

3-{2-[6-(3,5-Dichloro-4-hydroxy-benzoylamino)-3,7-dioxo-2-propyl-[1,2]diazepan-1-yl]-acetylamino}-4-oxo-butyric acid (11c) was prepared from N-{2-[(2-benzyloxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-3,7-dioxo-1-propyl-[1,2]diazepan-4-yl}-3,5-dichloro-4-hydroxy-benzamide (10d, diastereomers) (30 mg, 0.05 mmol) by the method used to prepare 11a to afford 19 mg (74% yield) of the title compound. 1H-NMR (500 MHz, CDCl3/CD3OD=0.5 mL/3 drops) δ 0.90-0.95 (t, 3H), 1.60-1.70 (m, 2H), 2.00-2.10 (m, 1H), 2.25-2.36 (m, 1H), 2.48-2.82 (m, 3H), 2.98-3.10 (m, 1H), 3.20-3.35 (m, 1H), 3.90-4.50 (m, 4H), 4.95-5.08 (m, 1H), 7.62-7.72 (m, 2H). Analytical HPLC: 5.40 min. LC-MS (ES+): m/e=531, 533 (M+H+).

Provenance & Evidence