Allyl bromide → HCID 18463949, compound

HRID 2231083Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([Cl:35])[C:33]=1[OH:34])[C:5]([NH:7][CH:8]1[C:14](=[O:15])[N:13]([CH2:16][C:17]([NH:19][CH:20]([CH:25]=[O:26])[CH2:21][C:22]([OH:24])=[O:23])=[O:18])[N:12]([CH2:27]CC)[C:11](=[O:30])[CH2:10][CH2:9]1)=[O:6].C(Br)C=C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([Cl:35])[C:33]=1[OH:34])[C:5]([NH:7][CH:8]1[C:14](=[O:15])[N:13]([CH2:16][C:17]([NH:19][CH:20]([CH:25]=[O:26])[CH2:21][C:22]([OH:24])=[O:23])=[O:18])[N:12]([CH3:27])[C:11](=[O:30])[CH2:10][CH2:9]1)=[O:6]

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 18463946HCID 18463946, compound

Product 1

HCID 18463949HCID 18463949, compound

Procedure

3-{2-[6-(3,5-Dichloro-4-hydroxy-benzoylamino)-3,7-dioxo-2-methyl-[1,2]diazepan-1-yl]-acetylamino}-4-oxo-butyric acid (11d) was prepared according to the method used to prepare (11c) only substituting iodomethane for allyl bromide.

Sources & evidence

ORD record: ord-a0da7f82b9c340c7a13daafee835077d
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06426413B1

Reaction notes

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