HCID 69686346, compound → HCID 69686346, compound

Participants

Reaction Steps

2-(6-Amino-2-methyl-3,7-dioxo-[1,2]diazepan-1-yl)-propionic acid ethyl ester (16) was prepared from 2-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-3,7-dioxo-[1,2]diazepan-1-yl]-propionic acid ethyl ester (15) by the method used to prepare 6a to afford 143 mg (73% yield) of the title compound as a mixture of diastereomers. 1H-NMR (500 MHz, CDCl3) δ 1.22-1.30 (m, 2.5H), 1.47-1.50 (d, 0.5H), 1.52-1.70 (m, 3H), 1.70-1.82 (m, 1H), 2.30-2.40 (m, 1H), 2.48-2.69 (m, 1H), 2.75-2.82 (m, 0.5H), 3.03-3.11 (m, 0.5H), 3.22 (d, 3H), 3.61-3.75 (m, 1H), 4.18-4.30 (m, 2H), 4.49-4.54 (m, 0.5H), 4.85-4.90 (m, 0.5H). Analytical HPLC: 3.90 and 4.06 min. LC-MS (ES+): m/e=258 (M+H+).

Provenance & Evidence