HCID 18463919, compound → HCID 18463919, compound

Participants

Reaction Steps

3-{2-[6-(3,5-Dichloro-4-hydroxy-benzoylamino)-2-methyl-3,7-dioxo-[1,2]diazepan-1-yl]-propionylamino}-4-oxo-butyric acid (20) was prepared from N-{2-[1-(2-benzyloxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-3,7-dioxo-[1,2]diazepan-4-yl}-3,5-dichloro-4-hydroxy-benzamide (19) (28 mg, 0.046 mmol) by the method used to prepare 11a, affording 17 mg (71% yield) of the title compound. 1H-NMR (500 MHz, CDCl3/CD3OD=0.5 mL/3 drops) δ 1.20-1.50 (m, 3H), 1.90-2.10 (m, 1H), 2.25-2.85 (m, 4H), 3.10-3.40 (m, 3H), 4.05-4.50 (m, 1H), 4.55-4.65 (m, 1H), 4.75-5.05 (m, 2H), 7.72-7.76 (m, 2H). Analytical HPLC: 7.51 min. LC-MS (ES+): m/e=517, 519 (M+H+).

Provenance & Evidence