HCID 18463938, compound → HCID 86758388, compound

Participants

Reaction Steps

[6-(4-Allyloxy-3,5-dichloro-benzoylamino)-2-methanesulfonyl-7-oxo-[1,2]diazepan-1-yl]-acetic acid (25) was prepared from [6-(4-allyloxy-3,5-dichloro-benzoylamino)-2-methanesulfonyl-7-oxo-[1,2]diazepan-1-yl]-acetic acid tert-butyl ester (24) by the method used to prepare 8a to afford 173 mg (100% yield) of the title compound. 1H-NMR (500 MHz, CDCl3) δ 1.74-1.77 (m, 1H), 1.91-1.93 (m, 1H), 2.22-2.25 (m, 2H), 3.19 (s, 3H), 3.39-3.44 (m, 1H), 4.24-4.28 (m, 2H), 4.61-4.63 (m, 2H), 4.71-4.75 (d, 1H), 5.12-5.15 (m, 1H), 5.28-5.31 (m, 1H), 5.40-5.44 (m, 1H), 6.10-6.16 (m, 1H), 7.31-7.33 (d, 1H), 7.79 (s, 2H). Analytical HPLC: 5.70 min. LC-MS (ES+): m/e=494, 496 (M+H+).

Provenance & Evidence