反应详情

温度

0 °C

4-(Methylthio)benzyl alcohol (50 mmol, 7.71 g) was dissolved in methanol (150 ml) and cooled to 0° C. Oxone® (110 mmol, 67.6 g) in water (250 ml) was added. The stirred mixture was warmed to room temperature after 5 minutes. After 40 minutes, the mixture was diluted with water (250 ml), and extracted with methylene chloride (300 ml, then 2×100 ml). The combined organic layers were dried (MgSO4), filtered through silica, and concentrated to afford the title compound (5.48 g, 58%) as a waxy solid.

1. temperatureThe stirred mixture was warmed to room temperature after 5 minutes
2. extractionextracted with methylene chloride (300 ml
3. dry with materialThe combined organic layers were dried (MgSO4)
4. filtrationfiltered through silica
5. concentrationconcentrated