反应详情

A mixture of 2-(4-aminophenyl)-9-chloro-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one in acetic anhydride is refluxed under heating for 8 hours. After the acetic anhydride is distilled off, the residue is extracted with chloroform. The extract is washed with water and dried over magnesium sulfate anhydride. The chloroform is distilled off to give 2-(4-acetamidophenyl)-9-chloro-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one.

1. temperatureis refluxed
2. temperatureunder heating for 8 hours
3. distillationAfter the acetic anhydride is distilled off
4. extractionthe residue is extracted with chloroform
5. washThe extract is washed with water
6. dry with materialdried over magnesium sulfate anhydride
7. distillationThe chloroform is distilled off