Chloride → HCID 14281453, compound

Participants

Reaction Steps

A mixture of 3.0 g of 1,8-naphthalic anhydride, 50 ml of methyline chloride and 2.1 g of 1H-imidazole-1- butanamine was stirred at room temperature for 20 hours. The insoluble product was isolated by filtration, washed with methlene chloride and then ether and dried in vacuo. The solid was placed in a round-bottom flask and immersed in an oil bath at 150° C., and the temperature was increased over a 45 minute period to 165° C. The reaction mixture was allowed to cool and the residue was triturated with ethyl acetate and recovered by filtration. After recrystallization from ethanol, the desired product melted at 153°-155° C.

Provenance & Evidence