HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetoxyacetyl chloride → 5-(N-methylacetoxyacetylamino)-2,4,6-triiodo-isophthalic acid dichloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetoxyacetyl chloride | HCID 26297 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 2,4,6-Triiodo-5-(methylamino)-1,3-benzenedicarbonyl dichloride | HCID 21466704 | — |
| Product | 5-(N-methylacetoxyacetylamino)-2,4,6-triiodo-isophthalic acid dichloride | HCID 88753858 | 98.8% |
Reaction Steps
A solution of 32 g of 5-methylamino-2,4,6-triiodoisophthalic acid dichloride (0.0525 moles in 80 ml of DMAC is treated dropwise at 0° to 5° C. with stirring with 10.7 g of acetoxyacetylchloride. Subsequently, stirring is continued over night and at room temperature. The reaction solution is stirred into ice water. A total of 36.7 g of 5-(N-methylacetoxyacetylamino)-2,4,6-triiodo-isophthalic acid dichloride, melting at 198°-200° C., are obtained, corresponding to a theoretical yield of 98.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04352788 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-e75feeafe2844a9cb0383eae4fc8be2a |
| Source note | uspto-grants-1982_10 |