HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-cyclopropylbenzene-1,2-diamine → 1-Cyclopropyl-2-methyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-cyclopropylbenzene-1,2-diamine | HCID 10582926 | — |
| Reactant | Triethylorthoaceate | HCID 21875354 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Cyclopropyl-2-methyl-1H-benzimidazole | HCID 21286283 | 94.4% |
Reaction Steps
A solution of 1.71 g (0.0115 mole) of N-cyclopropyl-1,2-phenylenediamine and 2.12 ml (0.0115 mole) of triethylorthoacetate in 50 ml of ethyl acetate was heated to reflux for 2 hours. The solvent was removed and the residue partitioned between chloroform and water. The organic phase was separated, dried over sodium sulfate and concentrated to give 1.87 g of a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782050 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-675887b0d42e428d85ed6c177ce0e9ed |
| Source note | uspto-grants-1988_11 |