HuagongsheHuagongshe Chemistry Print Report · For research reference only
Selenium Dioxide → 1-Cyclopropyl-1H-benzimidazole-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | 1-Cyclopropyl-2-methyl-1H-benzimidazole | HCID 21286283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Cyclopropyl-1H-benzimidazole-2-carbaldehyde | HCID 15072058 | 57.6% |
Reaction Steps
Selenium dioxide (1.2 g, 0.011 mole) was added to 60 ml of dioxane containing 1.87 g .(0.011 mole) of 1-cyclopropyl-2-methylbenzimidazole and the reaction heated to reflux for 2.5 hours. The reaction was filtered and the filtrate concentrated to a dark oil, 3.0 g. Chromatographing of the residue on silica gel gave 1.18 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782050 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-e0ecb81061674e09bdf6a889217e79f0 |
| Source note | uspto-grants-1988_11 |