Hydrochloric Acid → HCID 21286284, compound

Participants

Reaction Steps

To a solution of 7.8 g (0.53 mole) of 2-methylbenzimidazole N-oxide [Chem. Pharm. Bull., 11, 1375 (1963)]in 50 ml of dimethylformamide was added 2.53 g (0.053 mole) of 50% sodium hydride in oil over a period of 5 minutes. After stirring 15 minutes, 3.33 ml (0.053 mole) of methyl iodide was added over a 15-minute period and the reaction mixture allowed to stir at room temperature for 3 hours. The reaction was poured into water, the pH adjusted to 2 with 12N hydrochloric acid and the impurities extracted with ethyl acetate. The pH was adjusted to 12 with 6N sodium hydroxide solution and the product extracted with ethyl acetate (3×100 ml). The extracts were combined, dried over magnesium sulfate and evaporated under a nitrogen stream.

Provenance & Evidence