Acetic Anhydride → HCID 14262259, compound

HRID 2231262Notes

Reaction equation

HRID 2231262 reaction equation
[OH:1][CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(O)(=O)C>[C:12]([O:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[N:4]=1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 785692-(Hydroxymethyl)-1H-benzimidazole

Product 1

HCID 14262259HCID 14262259, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 1.0 g of 2-hydroxymethylbenzimidazole and 0.64 ml of acetic anhydride in 10 ml of acetic acid was heated to reflux for 1 hour. The solvent was removed in vacuo and the residue dissolved in chloroform and washed with a sodium bicarbonate solution. The organic layer was separated, dried and concentrated to give 1.2 g of the desired intermediate.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customThe solvent was removed in vacuo
  4. dissolutionthe residue dissolved in chloroform
  5. washwashed with a sodium bicarbonate solution
  6. customThe organic layer was separated
  7. customdried
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-ac813f09b4d5445cb880f9cbae5aeaac
Source dataset
uspto-grants-1988_11
Patent number
US04782050

Reaction notes

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