N~1~-Ethyl-4-fluorobenzene-1,2-diamine → 1-ethyl-5-fluoro-2-methylbenzimidazole

Participants

Reaction Steps

To 2.92 g of N-ethyl-4-fluorophenylenediamine in 15 ml of ethanol was added 3.49 ml of triethylorthoacetate and the reaction refluxed for 6 hours. The solvent was removed and the residue partitioned between ethyl acetate and water. The organic phase was separated, dried and the solvent removed to give 2.87 g of product as a brown oil.

Provenance & Evidence