HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 5,6-Difluoro-1,2-dimethyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 21193128 | HCID 21193128 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Difluoro-1,2-dimethyl-1H-benzimidazole | HCID 21286280 | — |
Reaction Steps
Using the alkylation procedure of Preparation A-2, 3.6 g of 2-methyl-5,6-difluorobenzimidazole, 1.03 g of 50% sodium hydride and 1.33 ml of methyl iodide in 40 ml of dimethylformamide gave 1.1 g of the desired product as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782050 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-5281f79268e747f2a86c404d6e0d51dc |
| Source note | uspto-grants-1988_11 |