HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Hydroxybenzo(b)thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Amino-3-Oxopropanoic Acid | HCID 75367 | — |
| Reactant | o-Mercaptophenylmalonamic acid | HCID 14257936 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Hydroxybenzo(b)thiophene-3-carboxamide | HCID 14257934 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Under a nitrogen atmosphere, a mixture of o-mercaptophenylmalonamic acid (2.1 g, 0.01 m), dimethylformamide (20 ml), and concentrated hydrochloric acid (0.2 ml) are heated in an oil-bath at ca. 100° C. until thin-layer chromatography indicates the absence of starting malonamic acid. The cooled, stirred mixture is diluted with ice-water, aged and filtered to yield 2-hydroxybenzo(b)thiophene-3-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782080 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-d394fa241c264d91bca83506640d7a32 |
| Source note | uspto-grants-1988_11 |