HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-benzyl-2-hydroxybenzo(b)thiophene-3-carboxamide → 2-Hydroxybenzo(b)thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-benzyl-2-hydroxybenzo(b)thiophene-3-carboxamide | HCID 21286565 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Hydroxybenzo(b)thiophene-3-carboxamide | HCID 14257934 | — |
Reaction Steps
A mixture of N-benzyl-2-hydroxybenzo(b)thiophene-3-carboxamide (4.3 g, 0.016 m), 10% palladium on carbon (2.0 g), and ethanol are stirred under a hydrogen atmosphere (40 p.s.i.) at 35° C. until hydrogen uptake is completed. The reaction mixture is filtered, the cake washed well with warm ethanol, and the combined filtrates concentrated in vacuo to yield 2-hydroxybenzo(b)thiophene-3-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782080 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-7e768eb2443e4420addbb902c7b45428 |
| Source note | uspto-grants-1988_11 |