Isobutyryl chloride → HCID 20522535, compound

Participants

Reaction Steps

To a solution containing 0.2 g of 5-hydroxy-3,3',7-trimethoxy-4'-(pivaloyloxy)-flavone in 3 ml of pyridine was added 0.05 ml of isobutyryl chloride and the mixture was stirred at room temperature for 3 hours. After removal of the solvent by evaporation under reduced pressure, the resulting oily residue was dissolved in 5 ml of a mixed solvent of ethanol and hexane (1:1, v/v). The solution was allowed to stand in a refrigerator overnight, during which time crystallisation occurred. The crystals were collected by filtration, washed with hexane and dried. There were obtained 200 mg of 5-(isobutyryloxy)-3,3',7-trimethoxy-4'-(pivaloyloxy)-flavone as colourless needles: m.p. 151°-152° C.

Provenance & Evidence