Trichloroacetyl chloride → 5-Chloro-6-methyl-4-trichloroacetoxy-2-trichloromethylpyrimidine
Reaction equation
[Cl:1][C:2]1[C:3]([OH:13])=[N:4][C:5]([C:9]([Cl:12])([Cl:11])[Cl:10])=[N:6][C:7]=1[CH3:8].[Cl:14][C:15]([Cl:20])([Cl:19])[C:16](Cl)=[O:17]>>[Cl:1][C:2]1[C:3]([O:13][C:16](=[O:17])[C:15]([Cl:20])([Cl:19])[Cl:14])=[N:4][C:5]([C:9]([Cl:10])([Cl:11])[Cl:12])=[N:6][C:7]=1[CH3:8]Participants
3
Procedure
The carboxylic ester compounds of the present invention may be prepared by reacting trichloroacetamidine with a selected acetoacetate to form the corresponding 4-hydroxy-2-trichloromethylpyrimidine, which is then reacted with a selected carboxylic acid chloride. These general reactions are illustrated below in equations (A) and (B). In equation (A), trichloroacetamidine is reacted with ethyl 2-chloroacetoacetate to form 5-chloro-4-hydroxy-6-methyl-2-trichloromethyl-pyrimidine. In equation (B), the 5-chloro-4-hydroxy-6-methyl-2-trichloromethylpyrimidine is reacted with trichloroacetyl chloride to form 5-chloro-6-methyl-4-trichloroacetoxy-2-trichloromethylpyrimidine. ##STR3##
Sources & evidence
- ORD record
- ord-9897b24e8bce452da34bf89e16737906
- Source dataset
- uspto-grants-1982_10
- Patent number
- US04352806
Reaction notes
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