Acetic Acid → Phenol, 4-[1,1-dimethyl-4-(3-phenoxyphenyl)butyl]-

Participants

Reaction Steps

A mixture of 5.0 g of 1-(3-phenoxyphenyl)-4-(4-methoxyphenyl)-4-methylpentane, 30 ml of 47% hydrobromic acid and 30 ml of acetic acid was refluxed for 8 hours. The reaction mixture was cooled to room temperature, poured into water, and extracted with benzene. The benzene solution was washed with water and dried, and benzene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography (silica gel; eluent: benzene) to give 4.2 g of 1-(3-phenoxyphenyl)-4-(4-hydroxyphenyl)-4-methylpentane.

Provenance & Evidence