Hydrochloric Acid → 3-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

Participants

Reaction Steps

A solution of 3-(4-fluorobenzoyl)butanoic acid (8 g), 4-hydroxypyridine (8 g) and sodium hydroxide (4.6 g) in water (80 ml) was heated in an autoclave at 140° C. for 20 hours. The reaction mixture was cooled and was acidified to pH 3-4 with dilute hydrochloric acid to afford as a white crystalline precipitate 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid, 9.45 g (87%), m.p. 250°-252° C.

Provenance & Evidence