反应详情

A solution of 3-(4-fluorobenzoyl)butanoic acid (885 g), 4-hydroxypyridine (663 g) and sodium hydroxide (453 g) in water (2.2 liters) was stirred under reflux for 24 hours. The reaction mixture was cooled, diluted with water (10 liters) and filtered through diatomaceous earth. The filtrate was acidified to pH 3 with concentrated hydrochloric acid to afford as a cream solid 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid, 1127 g (94%), m.p. 251°-254° C.

1. temperatureunder reflux for 24 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered through diatomaceous earth