反应详情

A mixture of 15.9 g. (0.1 mole) of 7-hydroxy-4-methylisoquinoline and 41.7 g. (0.125 mole) of triphenylphosphine dichloride is heated to 230° C. for four hours, cooled, and partitioned between chloroform and concentrated hydrochloric acid. The aqueous phase is neutralized with ammonium hydroxide and extracted with chloroform to yield 7-chloro-4-methylisoquinoline.

1. additionA mixture of 15.9 g
2. temperaturecooled
3. custompartitioned between chloroform and concentrated hydrochloric acid
4. extractionextracted with chloroform